Laboratory of Genetic Toxicity

Aims

• Study the genotoxic, mutagenic, clastogenic and/or recombinagenic potential of chemotherapics
• Investigate the mutagenic and genotoxic activity of dental materials
• Study the genotoxic and mutagenic action of environmental pollutants from industrial, urban and rural origin
• Evaluate the modulatory activity of common substances in the human diet and herbal extracts on genetic toxicity of different chemicals

Research Areas

• Induction of gene mutation, somatic recombination, genomic lesions and chromosome instability associated with drugs, dental products, plant extracts and other natural and synthetic compounds
• Genetic toxicity associated with environmental contamination
• Antigenotoxic potential of plant extracts and bioactive compounds present in the human diet
• Standardization of new methodologies applied to mutagenesis

Techniques and Services

• Somatic Mutation and Recombination Test (SMART) in Drosophila melanogaster (fruit fly)
• Comet Assay (Single Cell Gel Electrophoresis assay-SCGE) in somatic cells of Drosophila melanogaster
• Evaluation of in vivo genetic toxicity of drugs and phytotherapics, products currently used in dentistry, plant extracts and bioactive compounds present in the human diet and environmental samples
• Diagnosis of in vivo modulating activity - antimutagenesis - of plant extracts and bioactive compounds present in the human diet

Contacts

Mauricio Lehmann, Dr.; Rafael Rodrigues Dihl, Dr.

Phone: +55 51 3477-9214; + 55 51 3477-4000 (Extension 2422) --
E-mail: mauriciol@ulbra.br; rafael.rodrigues@ulbra.br

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